Gradual elimination of retroviruses in YBR/Ei mice.

Interstrain variation in amylase gene copy number and mRNA abundance in three mouse tissues.

Amylase expression in strain YBR differs in several respects from the standard mouse phenotype. The synthesis of salivary amylase is elevated twofold in YBR mice and the synthesis of pancreatic amylase is reduced to one-half the normal rate. We have compared the concentrations of amylase mRNA in the parotid, liver and pancreas of YBR mice with those in strains A/J and C3H. We observed differenc...

YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17

A variety of inherited animal models with different genetic causes and distinct genetic backgrounds are needed to help dissect the complex genetic etiology of glaucoma. The scarcity of such animal models has hampered progress in glaucoma research. Here, we introduce a new inherited glaucoma model: the inbred mouse strain YBR/EiJ (YBR). YBR mice develop a form of pigmentary glaucoma. They exhibi...

Evolution of the amylase multigene family. YBR/Ki mice express a pancreatic amylase gene which is silent in other strains.

The two isozymes of pancreatic amylase in mouse strain YBR/Ki are encoded by closely linked genes which are independently regulated. We have isolated these two pancreatic amylase genes, Amy-2.1 and Amy-2.2, from a cosmid library of YBR/Ki genomic DNA and compared the nucleotide sequences of coding regions with the amino acid sequences of the protein isozymes. Transcripts of both genes were also...

Isolation and Characlerization of Avian Retroviruses from the Cases of Malabsorption syndrome and Arthritis /Tenosynovitis in Chickens

The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-β production

Although activation of TLR4-positive cells is essential for eliminating Gram-negative bacteria, over-activation of these cells by the TLR4 ligand lipopolysaccharide (LPS) initiates a systemic inflammatory reaction and shock. Here we demonstrate that SPRET/Ei mice, derived from Mus spretus, exhibit a dominant resistance against LPS-induced lethality. This resistance is mediated by bone marrow-de...